Вот этот update касательно амбиена был сделан в январе этого года.
Zolpidem (Lexi-Drugs)
Special Alerts
FDA Recommending Lower Initial Zolpidem Doses to Reduce Risk of Morning Somnolence January 2013
The U.S. Food and Drug Administration (FDA) is requiring manufacturers of zolpidem products (Ambien®, Ambien CR®, Edluar™, and Zolpimist®) to change labeling to recommend lower starting doses of zolpidem in women. Blood levels in women may remain high enough the morning after use to impair activities that require alertness, including driving. Women appear to be more sensitive to this effect because they eliminate zolpidem more slowly than men, although the FDA is also recommending that the lower doses be considered for men. The recommendation is focused on zolpidem products approved for use immediately before bedtime. The FDA is recommending that the doses for immediate-release products be lowered from 10 mg to 5 mg and from 12.5 mg to 6.25 mg for extended-release products in women.